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古江勇

古江勇


博士,副研究员,硕士生导师

广州中医药大学杏林青年学者
学科: 药物化学
研究领域: 系统药理学

电话: 86-20-39318571
电子信箱: gujy@gzucm.edu.cn


简历

        2005.9-2009.7:北京大学化学与分子工程学院,理学学士(化学类)
        2009.9-2014.7:北京大学化学与分子工程学院,理学博士(化学生物学)
        2014.7-2016.6:北京大学生命科学学院,博士后(生物学)
        2016.7至今:    广州中医药大学第二临床医学院(广东省中医院),副研究员,杏林青年学者

研究领域和兴趣

        本课题组致力于系统药理学方法学研究及在中药药效物质基础探索中的应用。采用生物通路网络分析、分子模拟、计算生物学和数据挖掘研究药物在体内的作用机制,构建疾病生物通路及药物-系统相互作用网络,在系统水平进行药效评价,探索疾病的致病过程及治疗策略。本课题组主要的研究方向包括:
(1) 疾病及生物过程的通路构建;
(2) 基于生物通路网络的成药性指标开发;
(3) 中药药效定量计算;
(4) 中药表型组学研究平台开发。

加入我们

        热烈欢迎对系统药理学、分子模拟及中药物质基础研究感兴趣的本科生、研究生、博士后加入课题组。

联系信息

        联系人:古江勇
        地址:广州中医药大学第二临床医学院(广东省中医院)
        电话:86-20-39318571
        邮箱:gujy@gzucm.edu.cn

相关链接

        广州中医药大学
        广东省中医院
        全球天然产物数据库(UNPD)
        心血管疾病中草药数据库(CVDHD)
        银屑病中草药数据库(PDTCM)
        抗炎小分子数据库(AICD)

代表性论文

(1) Jiangyong Gu, Philip S. Crosier, Christopher J. Hall, Lirong Chen, Xiaojie Xu. Inflammatory pathway network-based drug repositioning and molecular phenomics. Molecular BioSystems, 2016, 12(9), 2777-2784.

(2) Jiangyong Gu1, Xinzhuang Zhang1, Yimin Ma, Na Li, Fang Luo, Liang Cao, Zhenzhong Wang, Gu Yuan, Lirong Chen, Wei Xiao, Xiaojie Xu. Quantitative modeling of dose-response and drug combination based on pathway network. Journal of Cheminformatics, 2015, 7, 19. (1co-first author)

(3) Fang Luo1, Jiangyong Gu1, Xinzhuang Zhang, Lirong Chen, Liang Cao, Na Li, Zhenzhong Wang, Wei Xiao, Xiaojie Xu. Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease. Scientific reports, 2015, 5, 10064. (1co-first author)

(4) Zhongyang Liu1, Feifei Guo1, Jiangyong Gu1, Yong Wang, Yang Li, Dan Wang, Liang Lu, Dong Li, Fuchu He. Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources. Bioinformatics, 2015, 31(11), 1788-1795.(1co-first author)

(5) Tengfei Chen1, Jiangyong Gu1, Xinzhuang Zhang, Yimin Ma, Liang Cao, Zhenzhong Wang, Lirong Chen, Xiaojie Xu, Wei Xiao. System-level Study on Synergism and Antagonism of Active Ingredients in Traditional Chinese Medicine by Using Molecular Imprinting Technology. Scientific reports, 2014, 4, 7159. (1co-first author)

(6) Xinzhuang Zhang1, Jiangyong Gu1, Liang Cao, Yimin Ma, Zhenzhen Su, Fang Luo, Zhenzhong Wang, Na Li, Gu Yuan, Lirong Chen, Xiaojie Xu, Wei Xiao. Insights into the inhibition and mechanism of compounds against LPS-induced PGE2 production: a pathway network-based approach and molecular dynamics simulations. Integrative Biology, 2014, 6(12):1162-1169.(1co-first author)

(7) Weixian Ding1, Jiangyong Gu1, Liang Cao, Na Li, Gang Ding, Zhengzhong Wang, Lirong Chen, Xiaojie Xu, Wei Xiao. Traditional Chinese Herbs as Chemical Resource Library for Drug discovery of Anti-infective and Anti-inflammatory. Journal of Ethnopharmacology, 2014, 155(1), 589-598. (1co-first author)

(8) Tengfei Chen1, Jiangyong Gu1, Hao Wang, Gu Yuan, Lirong Chen, Xiaojie Xu, Wei Xiao. Semi-Preparative Scale Separation of Emodin from Plant Extract by Using Molecularly Imprinted Polymer as Stationary Phase. Chromatographia, 2014, 13-14, 893-899. (1co-first author)

(9) Fang Luo1, Jiangyong Gu1 , Lirong Chen, Xiaojie Xu. Systems pharmacology strategies for anticancer drug discovery based on natural products. Molecular BioSystems, 2014, 10(7), 1912-1917. (1co-first author)

(10) Jiangyong Gu1, Fang Luo1, Lirong Chen, Gu Yuan, Xiaojie Xu. A systematic study of chemogenomics of carbohydrates. Molecular BioSystems, 2014, 10(3), 391-397. (1co-first author)

(11) Jiangyong Gu, Yuanshen Gui, Lirong Chen, Gu Yuan, Xiaojie Xu. CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology. Journal of Cheminformatics, 2013, 5, 51.

(12) Jiangyong Gu, Lirong Chen, Gu Yuan, Xiaojie Xu. A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, 2013 (2013), 203614.

(13) Jiangyong Gu, Yuanshen Gui, Lirong Chen, Gu Yuan, Hui-Zhe Lu, Xiaojie Xu. Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology. PLoS ONE, 2013, 8(4), e62839.

(14) Jiangyong Gu, Qian Li, Lirong Chen, Youyong Li, Tingjun Hou, Gu Yuan, Xiaojie Xu. Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy. Evidence-Based Complementary and Alternative Medicine, 2013 (2013), 425707.

(15) Jiangyong Gu, Hu Zhang, Gu Yuan, Lirong Chen, Xiaojie Xu. Surface-initiated molecularly imprinted polymeric column: In situ synthesis and application for semi-preparative separation by high performance liquid chromatography. Journal of Chromatography A, 2011, 1218(45), 8150-8155.

(16) Jiangyong Gu, Hu Zhang, Lirong Chen, Shun Xu, Gu Yuan, Xiaojie Xu. Drug–target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus. Computational Biology and Chemistry, 2011, 35(5), 293-297.

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